Orexin was found to induce panic, anxiety like behaviors in animal models.[52] Conversely, in an animal panic model, OX1R antagonist treatment reduced panic like behavior and alleviated anxiety inducing symptoms.[53] A study involving 56 drug-free adolescents diagnosed with any anxiety disorder other than specific phobias and 32 healthy controls found that the OXA level of anxiety patients was significantly higher than that of the control group (P < .001).[54]. The gene discussed is HCRTR1; the disease is Anxiety.