Fang et al reported that FAP overexpression in solid tumor tissue was significantly associated with poor overall survival and tumor progression.[22] Conformably, FAP was supposed to be significantly associated with tumor size and clinical stage in osteosarcoma.[23] It has also been predicted to play a novel role in the attachment of synovial fibroblasts to cartilage, which further contributes to proteoglycan loss and cartilage degradation.[24] THY1 also known as CD90, is widely regarded as a cell surface marker for sorting a subpopulation of fibroblasts in the heart. The gene discussed is THY1; the disease is osteosarcoma.