The KEGG analysis indicated that the upregulated DEGs in HF enriched in 14 pathways and the top 5 of the enriched pathways were African trypanosomiasis, malaria, cAMP signaling pathway, AGE-RAGE signaling pathway, and asthma (Supplementary Table 2, http://links.lww.com/MD/J209; Fig. 3C). The gene discussed is RENBP; the disease is asthma.