As a crucial process of oncogenesis and development, angiogenesis is necessary for primary tumor cells’ growth, invasion, and metastasis.[16] Moreover, VEGF overexpression has been reported in many malignancies.[17] Over 30 SNPs were previously reported in the VEGF gene; parts have been demonstrated to modulate VEGF expression levels[18] and may be associated with cancer susceptibility. The gene discussed is VEGFA; the disease is cancer.