The model established in this study to predict 2 year-OS in pleural leukoplakia, pleural hyperemia, pleural adhesion, treatment regimen, and serum CEA level in patients with EGFR mutation-positive lung adenocarcinoma pleural invasion in terms of gender, lymph node metastasis and gross pleural view under medical thoracoscope is accurate and feasible. Here, CEACAM5 is linked to lung adenocarcinoma.