Several studies indicated that there was no correlation between the expression of ki-67 and EGFR mutation,[32] but some studies also found that patients in the low expression group of Ki-67 were more prone to EGFR gene mutation than those in the high expression group of ki-67.[33] Genetic analysis of lung adenocarcinoma pathways has shown that the cell cycle stimulation pathway is closely associated with prognosis and differentiation of lung adenocarcinoma subsets with increased solid components. This evidence concerns the gene EGFR and lung adenocarcinoma.