The model established in this study to predict 2 year-OS in pleural leukoplakia, pleural hyperemia, pleural adhesion, treatment regimen, and serum CEA level in patients with EGFR mutation-positive lung adenocarcinoma pleural invasion in terms of gender, lymph node metastasis and gross pleural view under medical thoracoscope is accurate and feasible. This evidence concerns the gene EGFR and lung adenocarcinoma.