Among gliomas, Shen-6 with a higher Ki-67 index showed more aggressive and invasive activity through glioma,[26] bladder tumor,[27] and anal carcinoma.[28] As Scholzen and Gerdes reported in their review, the Ki-67 index predicted survival of multiple myeloma,[25] soft tissue sarcoma, prostate cancer, and breast cancer. Here, MKI67 is linked to anal carcinoma.