Notably, in a pan-cancer analysis of TCGA, Pan-China, and Memorial Sloan Kettering Cancer Center (MSKCC) data (Fig. 7I), ATR is the only cell cycle checkpoint kinase that is comutated with TP53 in all three datasets (cumulative log2 odds ratio = 0.968, cumulative q < 0.001). This evidence concerns the gene TP53 and cancer.