However, the addition of DIM activates CHK2 twice as much as estrogen deprivation alone (P = 0.02) (Fig. 8D; 11-fold increase over estrogen-supplemented tumors, P = 0.007) to further suppress tumor growth (P = 0.005) (Fig. 8E) and proliferation (P = 0.008) (Fig. 8F). The gene discussed is CHEK2; the disease is neoplasm.