A significant increase of MMP1 mRNA in 2 of 3 studies, LOX mRNA in 1 of 3 studies with a trend toward increased expression in a second study (P ≤ .08 in TCGA Firehose Legacy), uPAR mRNA in all 3 studies, and α-SMA mRNA in 1 of 3 studies with a trend toward increased expression in the TCGA Firehose Legacy study (P ≤ .06) were identified in the high VEGF mRNA group compared to the low VEGF group, consistent with the changes observed in the tumor xenograft studies. The gene discussed is LOX; the disease is neoplasm.