In a murine intrahepatic cholangiocarcinoma model, blocking placental growth factor (PIGF)-α, a member of the VEGF family, impacted only one subset of CAFs that expressed low levels of Col1.67 Reduction of FAP-α expressing CAFs may have contributed to the changes in the ECM observed here. The gene discussed is VEGFA; the disease is intrahepatic cholangiocarcinoma.