A significant increase of MMP1 mRNA in 2 of 3 studies, LOX mRNA in 1 of 3 studies with a trend toward increased expression in a second study (P ≤ .08 in TCGA Firehose Legacy), uPAR mRNA in all 3 studies, and α-SMA mRNA in 1 of 3 studies with a trend toward increased expression in the TCGA Firehose Legacy study (P ≤ .06) were identified in the high VEGF mRNA group compared to the low VEGF group, consistent with the changes observed in the tumor xenograft studies. This evidence concerns the gene ACTA1 and neoplasm.