In addition, although not investigated here, a previous study described different profiles of Fc-effector functionality within the panel of isolated cross-reactive antibodies from a patient who had recovered from SARS.36 In that study, cross-reactive antibodies targeting diverse epitopes on the S protein demonstrated Fc-effector function in vitro, including antibody-dependent cellular phagocytosis, antibody-dependent cellular trogocytosis, and antibody-dependent complement deposition. The gene discussed is PROS1; the disease is severe acute respiratory syndrome.