Some downregulated miRNAs (miR-126-5p, miR-132-3p, miR-146a-5p, miR-15b-5p, miR-152-3p, miR-155-5p, miR-181a-5p, miR-196b-5p, miR199a-5p, miR-21-5p, miR-214-3p, miR-222a-3p, miR-23a-5p, miR-29b-3p, and miR-98-5p) are directly linked to the activation of inflammatory signaling molecule NF-κB which could be involved in the pathogenesis and progression of endometriosis [33, 50, 62, 63]. The gene discussed is NFKB1; the disease is endometriosis.