The anti-inflammatory cytokine IL-10 was significantly decreased (53% decrease, P =  < 0.001), while the inflammatory markers IL-17 (2.8-fold increase, P =  < 0.001) and CRP (9.38 folds increase, P =  < 0.001) increased in the untreated arthritis group versus the control group. The gene discussed is IL17A; the disease is arthritic joint disease.