IL10 and arthritic joint disease: While IL-10 which is an anti-inflammatory cytokine is upregulated with Toxoplasma infection, as discovered in many studies, to suppress host immunity for infection survival (Jeong et al. 2016; Neyer et al. 1997; Khan et al. 1995), the same effect appeared on arthritis model (Washino et al. 2012; Hafez et al. 2020).