One additional evidence is that, it is known that innate immune colitis in Rag−/− mice following infection with Helicobacter hepaticus is IL-23 dependent, and IL-23R expression is controlled by transcription factor ROR-gammat, while Rag−/−Rorc−/− mice failed to develop innate colitis, suggesting that IL-23 has an positive effect on improving IBD (Hue et al., 2006; Buonocore et al., 2010; Ermann et al., 2014; Hall et al., 2017). This evidence concerns the gene IL23A and colitis.