miRNA regulates NF-κB, STAT3, PI3K/AKT and other pathways to modulate the synthesis and release of inflammatory factors and promote the repair of the intestinal mucosal barrier and epithelial barrier, thereby inhibiting colitis in mouse models and alleviating intestinal inflammation in IBD patients in the clinical setting (Innocenti et al., 2022). Here, STAT3 is linked to colitis.