NLRP6 and colitis: The characteristic alteration of NLRP6 deficiency in mouse colonic epithelial cells is that exposure to DSS worsens colitis, and the resultant increased abundance of phylum Bacteroidetes (Prevotellaceae) can produce DSS-induced colitis by inducing CCL5 in neonatal or adult wild-type mice (Elinav et al., 2011).