Obesity leads to adipocyte hypertrophy and increased macrophages, and the increase in macrophages facilitates the production of gene products of the proinflammatory environment; adipocytes can secrete the proinflammatory cytokines IL-6, hs-CRP, and TNF-α, leading to an inflammatory state in the organism (Cox et al., 2015). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.