FOXP3 and asthma: In addition, it was found that acetic acid is associated with the development of asthma; acetic acid can regulate the onset and development of asthma by activating the GPR43 receptor to inhibit HDAC9 activity, increasing the transcriptional level of the Foxp3 gene, and promoting Treg cell proliferation and immunosuppressive function (Zeng and Chi, 2015).