t(11;18)(q21;q21)/BIRC3::MALT1 occurs frequently in MALT lymphoma of the stomach (24%) and lung (40%), but rarely in other sites.25,51 t(1;14)(p22;q32)/IGH::BCL10, t(14;18)(q32;q21)/IGH::MALT1 and t(3;14)(p14;q32)/IGH::FOXP1 are infrequent, and lead to overexpression of the involved oncogene, respectively.52,53,69 BCL10 and MALT1 are a component of the signaling complex connecting BCR to the canonical NF-kB pathway, and their overexpression by translocation causes constitutive NF-kB activities. The gene discussed is MALT1; the disease is MALT lymphoma.