IFNA1 and colorectal carcinoma: While in this study, we tried to employ a holistic strategy with a high-quality proteomics analysis that discerned the crosstalk between antiviral response and cancerous pathways in HA-CRC, leading us to biologically reveal a critical role of EVs released from defective HIV-1 reservoir cells (8E5 cells) in activating IFN pathways in macrophages.