Comparing with the non-HA-CRC group, antiviral response and its associated inflammation were found to be significantly enriched (Fig. 6A), which involved in the up-regulation of EIF2AK2, ADAR, MX2, DDX58, MYD88 and IFI16, as well as the down-regulation of HSPB1 (Fig. 6B). Here, EIF2AK2 is linked to colorectal carcinoma.