Angiotensin 1–7 (ANG 1–7), which is hydrolysed from angiotensin II (ANG II) by angiotensin-converting enzyme 2 (ACE2), exhibits potent antihypertrophic, antifibrotic, antioxidant and vasoprotective actions to counteract the harmful effects of ANG II signaling with promising clinical significance in the settings of both HF with reduced and preserved ejection fraction (Patel et al., 2016; Yu et al., 2018). The gene discussed is ANGPT1; the disease is hydrops fetalis.