We and others have shown that gene expression, endogenously produced ANG II levels, and the degree of subsequent hypertension can be precisely controlled in a dose- and time-dependent manner as well as in a reversible manner (Peters et al., 2008, 2009, 2012; Erbanová et al., 2009; Husková et al., 2010, 2016, 2021; Honetschlägerová et al., 2011b; Cunningham et al., 2013; Sporková et al., 2014; Jíchová et al., 2016; Sedláková et al., 2018). This evidence concerns the gene AGT and Hypertension.