Heparan-sulfate proteoglycans (HPSE) digestion-generated heparan sulfate fragments of about 10 kDa in B16B15b melanoma cell stimulated melanoma migration and angiogenesis, which were possibly due to signaling by some other unknown heparin-binding growth factor(s) (Roy and Marchetti, 2009). The gene discussed is HDGF; the disease is melanoma.