A map of single-cell sequencing in hepatocellular carcinoma (HCC) shows that in TECs, extracellular matrix organization genes such as COL4A2 and SPARC were upregulated, liver sinusoidal endothelial cell (LSEC) markers such as CLEC4G did not express, while macro-vascular endothelial cell (MVEC) markers such as PECAM1 (CD31), AQP1 and CD34 were also upregulated (Aizarani et al., 2019). This evidence concerns the gene AQP1 and hepatocellular carcinoma.