Interaction analyses on lncRNAs included in the prognostic model revealed two regulatory ceRNA axes potentially involved in the immune regulation of AML prognosis, namely, lncRNA MEG3/miR-125a-5p/SEMA4C and lncRNA HCP5/miR-125b-5p/IL6R. The gene discussed is SEMA4C; the disease is acute myeloid leukemia.