PTGR3 and Alzheimer disease: Furthermore, additional genome-wide DNA methylation studies of peripheral blood in AD/dementia have also been performed and have revealed a number of AD-linked loci annotated to NCAPH2, LMF2, B3GALT4 and ZADH2 (Lunnon et al., 2014; Di Francesco et al., 2015; Kobayashi et al., 2016; Shinagawa et al., 2016; Madrid et al., 2018; Lardenoije et al., 2019; Vasanthakumar et al., 2020; Perez et al., 2022).