In the current study, we identified the most significant DMPs (Padj < 0.05), including cg18771300, cg07157030, cg07189587, cg09656629, cg20186636, cg02821156, and cg06758191, in Chinese patients with AD relative to cognitively healthy controls, which aligned to RHOJ, PARK2, FLNC, ANKH, and AFAP1 genes (Figure 5), respectively. This evidence concerns the gene AFAP1 and Alzheimer disease.