Depending on the extent of laminin-α2 deficiency, the clinical manifestations of LAMA2 related muscular dystrophy (LAMA2-MD) range from severe congenital muscular dystrophy type 1A (MDC1A, OMIM#607855) to milder late-onset LAMA2-MD (OMIM#618138). This evidence concerns the gene LAMA2 and Menkes disease.