YTHDC1 and acute myeloid leukemia: A number of studies discovered a critical role for m6A-methylation in leukemogenesis.97 Cheng and coworkers recently reported aberrantly high expression of YTHDC1 (YTH domain containing 1) in cells from AML patients.12 YTHDC1 is a reader protein that recognizes m6A-methylation in RNA that is mediated by the METTL3 (methyltransferase 3), METTL14 (methyltransferase 14), and WTAP (Wilms tumor-associated protein) writer complexes in the nucleus, and regulates the efficiency of mRNA splicing, processing, and metabolism.