This interaction is mediated by phosphorylation of tyrosine residues in the IDR of the EWS moiety, necessary for the multimerization of EWS::FLI1 fusion with wild-type EWSR1 and for the formation of nuclear condensates that are composed of EWS::FLI1 and its interactors.5 Apart from oncogenes, also tumor-suppressive activity has been associated with biomolecular condensates. The gene discussed is EWSR1; the disease is neoplasm.