The UTX (ubiquitously transcribed X chromosome tetratricopeptide repeat protein) H3K27 demethylase acts as a tumor suppressor by regulating genome-wide histone modifications and higher-order chromatin interactions in a condensation-dependent manner.15 Strikingly, UTX mutations, which are found in several cancers, occur most frequently in the IDR of the protein, resulting in disrupted nuclear condensation of UTX and impaired tumor suppressive function. This evidence concerns the gene KDM6A and neoplasm.