XPO1 and acute myeloid leukemia: Two recent studies demonstrated that NPM1c chromatin binding recruits high local concentrations of RNA-Pol II and members of transcription elongation complexes into biomolecular condensates at transcriptionally active chromatin loci, such as the HOXA/B gene cluster.89,90 NPM1c binds to genomic sites with existing active transcription that are preoccupied by exportin 1 (XPO1) in AML blasts, but not in healthy CD34+ hematopoietic stem and progenitor cells.