For instance, the cyclin-dependent kinase 9 (CDK9) is frequently dysregulated in AML and activates leukemic gene expression programs via the mTOR signaling pathway.119 CDK9 was previously shown to localize to biomolecular condensates,120 but it is unclear whether pharmacological inhibition of CDK9 and the related kinases CDK7, CDK12 nor CDK13 has antileukemic potential via disruption of specific biomolecular condensates.121,122. Here, CDK9 is linked to acute myeloid leukemia.