CCR7 and neoplasm: Experiments confirmed that the cytoplasmic domain of the Mer receptor tyrosine kinase (MerTK) can also trigger cytotoxicity on tumor cells through CAR-M, and in vivo, the CAR-M that targets CCR7 prevents tumor metastasis and delays LDhiCCR7hi immunosuppressive cells from migrating from tumor tissue to distal organs, which prolongs survival and inhibits tumor growth.