Experiments confirmed that the cytoplasmic domain of the Mer receptor tyrosine kinase (MerTK) can also trigger cytotoxicity on tumor cells through CAR-M, and in vivo, the CAR-M that targets CCR7 prevents tumor metastasis and delays LDhiCCR7hi immunosuppressive cells from migrating from tumor tissue to distal organs, which prolongs survival and inhibits tumor growth. This evidence concerns the gene MERTK and neoplasm.