A similar strategy was reported by Powell Jr.’s Group (Rodriguez-Garcia et al., 2021), and they proved the selective elimination of FRβ+ TAMs by CAR-T cells enriched pro-inflammatory monocytes and stimulated tumor-specific CD8+ T-cells to infiltrate in the TME, eventually syngeneic tumor-bearing mice have delayed tumor progression and prolonged survival rate. The gene discussed is CD8A; the disease is neoplasm.