showed that mice administered fecal samples from subjects with metabolic syndrome and knee OA exhibited worse OA severity, higher mean circulatory concentrations of inflammatory factors (interleukin-6 (IL-6), IL-1β and macrophage inflammatory protein-1α) and increased intestinal permeability (20), which indicated dysbiosis of the intestinal microbiome played a crucial role in the pathogenesis of OA. Here, IL6 is linked to metabolic syndrome.