Further, the ICI-related prognosis analysis was performed, and it revealed that “B cells memory, NK cells resting, macrophages M0, macrophages M2, Dendritic cells activated and Mast cells activated” were risk factors in pan-cancer, while “B cells naïve, plasma cells, T cells CD8, T cell CD4 naïve, T cells follicular helper, dendritic cells resting and mast cell resting” were protective factors in pan-cancer (Figure 5H). The gene discussed is CD4; the disease is cancer.