Enhanced ICAM-1 expression on target tumor cells led to an increase in conjugation formation with PD-1high hHER2-CAR-T cells (Figure 4G) followed by greater lytic granule exocytosis (measured as CD107a expression), compared to PD-1low CAR-T cells (Figure 4H and Supplementary Figure 3). This evidence concerns the gene LAMP1 and neoplasm.