HIC1 and cancer: HIC1 was associated with worse OS in ACC (HR, 1.925; 95% CI, 1.171-3.164; P = 0.010), KIRP (HR, 2.886; 95% CI, 1.647-5.058; P < 0.001), LGG (HR, 2.104; 95% CI, 1.164-3.802; P =0.014), and UVM (HR, 9.243; 95% CI, 2.417-35.350; P = 0.001), while was correlated with better OS in UCEC (HR, 0.560; 95% CI, 0.372-0.844; P = 0.006) in the assessment of OS in pan-cancer (Figure 2A).