HIC1 and adrenal cortex carcinoma: For univariate Cox analysis of DFS, the results indicated that HIC1 was a risk factor in ACC (HR, 2.011; 95% CI, 1.052-3.846; P = 0.035), KICH (HR, 21.421; 95% CI, 1.127-407.252; P = 0.041), and KIRP (HR, 2.623; 95% CI, 1.246-5.524; P = 0.011), while was a protective factor in UCEC (HR, 0.386; 95% CI, 0.219-0.681; P = 0.001) (Figure 2B).