The results showed that HIC1 was abnormally higher in cancer samples in CHOL, glioblastoma multiforme (GBM), HNSC, KIRC, acute myeloid leukemia (LAML), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD), while was significantly downregulated in adrenocortical carcinoma (ACC), BLCA, BRCA, CESC, COAD, esophageal carcinoma (ESCA), KICH, LGG, LICH, LUAD, LUSC, ovarian serous cystadenocarcinoma (OV), prostate adenocarcinoma (PRAD), skin cutaneous melanoma (SKCM), testicular germ cell tumors (TGCT), THCA, UCEC, and uterine carcinosarcoma (UCS) (Figure 1E). This evidence concerns the gene HIC1 and colon adenocarcinoma.