Differential expression analysis indicated that HIC1 expression was strongly decreased in tumor samples in comparison with their compared normal samples of TCGA pan-cancer dataset in bladder urothelial carcinoma (BLCA), BRCA, cervical squamous cell carcinoma, and endocervical adenocarcinoma (CESC), COAD, kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), LUAD, LUSC, thyroid carcinoma (THCA) and uterine corpus endometrial carcinoma (UCEC), while was significantly increased in cholangiocarcinoma (CHOL), head and neck squamous cell carcinoma (HNSC), and KIRC (Figure 2D). The gene discussed is HIC1; the disease is cholangiocarcinoma.