Hypermethylated in Cancer 1 (HIC1), located on chromosome 17p13.3 completely within a CpG island, is a tumor repressor that is widely expressed in normal tissues, however, is generally lowly expressed with methylation in several cancers, such as prostate cancer, breast cancer, and pancreatic cancer (7–9). This evidence concerns the gene HIC1 and familial pancreatic carcinoma.