ACAN and rheumatoid arthritis: For rheumatoid arthritis, DC generated in the presence of GM-CSF+IL-4, and then supplemented with the NF-κB inhibitor Bay 11-7082, subsequently pulsed with citrullinated peptides of aggrecan, vimentin, collagen type II, and Aα and Bβ fibrinogen (putative RA autoantigens) conferred superior efficacy in vivo (210, 211).