For rheumatoid arthritis, DC generated in the presence of GM-CSF+IL-4, and then supplemented with the NF-κB inhibitor Bay 11-7082, subsequently pulsed with citrullinated peptides of aggrecan, vimentin, collagen type II, and Aα and Bβ fibrinogen (putative RA autoantigens) conferred superior efficacy in vivo (210, 211). This evidence concerns the gene CSF2 and rheumatoid arthritis.