In addition, tumor suppressors TP53, RB1, or CDKN2A, and telomere maintenance mechanisms play essential roles in aging regulation, and intriguingly, hDNAmad+ EC tumors had robustly higher frequencies of inactivation of TP53, RB1, and CDKN2A accompanied by significantly enhanced telomerase activity. The gene discussed is TP53; the disease is neoplasm.