Additional studies, have focused on disparate biomarkers, investigating either the role of suPAR in relation to vascular inflammation, thromboembolism and progression to respiratory failure and disease severity (26–30), the role of sTREM-1 as a sepsis biomarker and mortality predictor (15, 16, 31, 32), or how upregulation of HGF, an anti-inflammatory cytokine, predicted ICU admission and death probability (17, 33, 34). The gene discussed is HGF; the disease is Sepsis.