As the infiltration of inflammatory cells in the background has been previously associated with poor prognosis in PTCL, NOS (24, 25), we evaluated the phosphorylation status of STAT3-S727 (S727TILs) and its significance in TILs (Figures 3B, C). This evidence concerns the gene STAT3 and mature T-cell and NK-cell non-Hodgkin lymphoma.