The phosphorylation status of STAT3 in PTCL, NOS remains largely unknown, and the phosphorylation of STAT3 at another activation site, serine 727 (S727) has not been well studied, in contrast to the frequent observation of positive phosphorylation at Y705 in both ALK+ and ALK- ALCL. This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.