In humans, major inhibitory receptors are represented by certain Killer Ig-like Receptors (KIRs) and the CD94:NKG2A heterodimer, while the most known tumor-recognizing receptors include the Natural Cytotoxicity Receptors (NCRs) (NKp46, NKp30, and NKp44), NKG2D, and DNAM-1 (12, 13). Here, CD226 is linked to neoplasm.