FBP1 and lactic acidosis: FBP1 deficiency leads to hypoglycaemia and lactic acidosis during catabolic episodes, induced by prolonged fasting during infections, high fever or excessive fructose consumption indicated by following lab findings: hyperalaninemia, hyperketonemia, elevetaed ratio of lactate/pyruvate, increased plasma concentration of uric acid, glyceroluria and/or pseudo-hypertriglyceridemia (29–32).