The unadjusted model indicated that higher OPG levels were associated with a higher incidence of the primary outcome [HR: 2.20; 95% CI: (1.54,3.14); P < 0.001], all-cause death [HR, 1.81; 95% CI, (1.35,2.43); P < 0.001], cardiovascular death [HR, 1.75; 95% CI, (1.13,2.73); P = 0.01], and HF hospitalization [HR: 3.05; 95% CI: (1.73,5.36)]. This evidence concerns the gene TNFRSF11B and hydrops fetalis.