In DCM at pre-HF stage, the corin-ANP-cGMP axis, when biologically functional, counters the outcomes of the pathologically activated systemic and cardiac classical RAAS by maintaining cardio-renal homeostasis promoting diuresis, natriuresis, and vasodilation and anti-fibrotic action (4, 6, 40, 45, 46). This evidence concerns the gene NPPA and familial dilated cardiomyopathy.