In mouse HF models induced by left coronary artery ligation and transverse aortic constriction, intraperitoneal injection of a recombinant extracellular fragment of human corin with an engineered activation site lowered Ang II and aldosterone plasma levels, boosted cGMP levels, improved cardiac function and attenuated cardiac remodeling and fibrosis (22). This evidence concerns the gene CORIN and hydrops fetalis.