NPPB and chronic obstructive pulmonary disease: In this study, we aimed to assess the levels of BNP and their association with cardiac dysfunction in patients with COPD. The BNP levels were normal in COPD patients; however, it significantly predicts FAC and RV strain in this population. A study by Sharif et al. [30] demonstrated that BNP levels were correlated with RV remodeling as well as the severity of PH.