MMP3 and Cowden syndrome 1: The baseline WOMAC, VAS, and MMP-3 were comparable in both groups; in PRP it was found to be 60.45 ± 11.648, 7.20 ± 0.859, and 48.884 ±5.668, respectively, whereas, in the CS group, it was found to be 57.28 ± 11.012,6 .83 ± 0.946, and 47.884 ±4.668, respectively.