In the same study, the authors reported that TRPM8−/− mice housed at 21°C experienced late-onset obesity, probably due to diurnal hyperphagia and reduction of fat oxidation, suggesting that TRPM8 could regulate an optimal ingestive thermoregulatory response (Reimúndez et al., 2018). Here, TRPM8 is linked to obesity due to melanocortin 4 receptor deficiency.