In microglia and neurons isolated from dorsolateral prefrontal cortex of late-stage AD donors, another study profiling single-nuclei RNA-seq and ATAC-seq within the same nuclei showed that the transcription factors ZEB1 and MAFB may regulate transcription of approximately half the cis-regulatory elements contained in the chromatin that are unique to AD (Anderson et al., 2023). This evidence concerns the gene ZEB1 and Alzheimer disease.