HLA-DRB1 and Alzheimer disease: In the CK-p25 AD mouse model, this same subcluster also comprised 35 genes out of 480 that were identified as a microglial signature, such as HLA-DRB1 and MHC class II genes, as well as 49 genes that haven’t been identified previously in AD animal models, including genes coding for the pattern-recognition receptor CD14 and complement component C1QB (Mathys et al., 2019).