CRP and obesity due to melanocortin 4 receptor deficiency: C-reactive protein (CRP)—which is produced by the liver following stimulation by interleukin-6 generated by adipose tissue (12)—may be an important biomarker in this causal pathway, as it is an indicator of inflammation that has been shown to be strongly influenced by obesity (13) and increases the risk of cardiovascular disease (14) and atherosclerosis (15).