HAPLN1 and osteoarthritis: Four proteins were reduced, including the hyaluronan and proteoglycan link protein 1 (HAPLN1) and collagen alpha-1(I) chain (COL1A1), two proteins involved in the organization of the extracellular matrix (according to the Uniprot Gene Ontology database—GO:0030198) and associated with cartilage homeostasis and osteoarthritis (Tsezou, 2014; Jang et al., 2021).