We first assessed the expression of the ITGAL gene in different tumors using the GEPIA database and found that the gene was lowly expressed in kidney chromophobe (KICH), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), rectum adenocarcinoma (READ), thyroid carcinoma (THCA), and thymoma (THYM) compared to normal tissues. This evidence concerns the gene ITGAL and squamous cell lung carcinoma.