Studies have shown that after helminth infection of mice, the transcriptional profile of Th2 cells and ILC2 in the lung are closely related relative to naive CD4 T cells from the lung and Th2 cells from the lymph nodes (12), with Rora transcripts in Th2 cells correlated with activated and cytokine-secreting cells (11). The gene discussed is CD4; the disease is helminthiasis.