PTPRC and helminthiasis: Although there was an increase in lung ILC2s (CD45+CD3−CD4−SiglecF−CD11b−CD127+KLRG1+GATA3+; Supplemental Fig. 3A) after N. brasiliensis infection in WT BMC mice (Fig. 2B), Rorasg/sg BMC mice did not have an increase in the number of lungs ILC2s and had significantly (p < 0.01 and p < 0.5, respectively) fewer ILC2s compared with WT BMC after primary and secondary helminth infection (Fig. 2B).