CD274 and neoplasm: For instance, VEGF receptor inhibitors can enhance the efficacy of anti‐programmed cell death ligand 1 (PD‐L1) and anti‐PD‐1 drugs through their immunomodulatory role,34, 35 while PD‐1 inhibitors can reduce tumor angiogenesis; the combination of the two has a synergistic antitumor effect.36