SKAP2 and acute respiratory distress syndrome: Exposure to stress, specifically starvation, enhances secretory autophagy and decreases degradative autophagy by inducing a loss of lysosomal integrity.[14] Recent studies on SAPs have focused on unraveling their role in the occurrence and development of diseases, such as cancers[15] and acute respiratory distress syndrome (ARDS)[16] suggesting a promising strategy for the diagnosis and mechanistic studies of these diseases.