Our previous study reported the augmenting effect of L‐HCC‐sEVs in liver tumor formation and distant metastasis.[12] Here, we observed that more extensive microvessels were formed in tumors derived from subcutaneous co‐injection of PLC/PRF/5 cells with HCC‐sEVs than in tumors developed from cells co‐injected with or without normal‐sEVs (Figure 1C,D). Here, HSPG2 is linked to hepatocellular carcinoma.