Substantial elevation of vWF along with coagulation factor VIII has been found in lymphoma and leukemia patients.[21] An abundance of vWF in blood is detected in gastric cancer[14d] and is closely associated with cancer thromboembolism in malignant breast cancer.[14c] Although high levels of vWF are frequently observed in a variety of cancers, a contradictory prognostic value of vWF has been noted. This evidence concerns the gene F8 and cancer.