In accordance with the elevated protein level of vWF in the sEVs of HCC patients and cell lines, vWF mRNA expression was upregulated in tumor tissue relative to the normal tissue in 50 paired in‐house cases of tumor and nontumorous (NT) liver tissues and in samples from the TCGA and GSE6764 databases of liver cancer (Figure 2H–J). The gene discussed is VWF; the disease is neoplasm.