FGFR1 and hepatocellular carcinoma: FGF2 belongs to the fibroblast growth factor family and exerts its effects by binding to four FGFR tyrosine kinase receptors (FGFR1–4).[19] We wondered which FGFR was responsible for the effect of FGF2 in HCC cells; thus, the expression of FGFR copy number in various HCC cell lines was examined (Figure S5, Supporting Information).