vWF could also link up platelets and tumor cells within the circulation to form heteroaggregates that develop resistance against anoikis and escape immune surveillance during the process of distal metastasis.[34] It also facilitates cancer metastasis by accelerating the attachment of tumor cells to the microvasculature, which allows extravasation of tumor cells.[35] In the same vein, we found that HCC‐derived sEV–vWF activates endothelial cells, aiding the attachment of tumor cells to the endothelium. This evidence concerns the gene VWF and neoplasm.