PRR15 and brain cancer: By searching for this gene in the Human Tissue Map provided by the PETCH-DB, we found that the PRR15 gene had the lowest 5hmC modification levels in the brain from all five donors compared with other organs (Figure 4A), thus providing the information about the baseline tissue-specificity of PRR15 gene and its potential relevance to the brain biology, although this gene was initially identified only in plasma cfDNA derived from patients with brain cancer.