Overall, compared to the controls, 13 of 22 selected SNPs were initially associated with the risk of HER2‐zero BC (ORs for heterozygote/rare homozygotes ranging from 1.10 to 1.27), while 15 SNPs were initially associated with HER2‐low BC (ORs ranging from 1.08 to 1.24) (Figure 3A,D; and Table S6). The gene discussed is ERBB2; the disease is breast cancer.