We found that patients with HRR gene mutations had low expression of antigen presentation‐related genes such as CD40, HLA‐DQB1, HLA‐DRB5, IFNA1, and IL1A, which may indicate that HRR mutations reduce the antigen presentation response and increase plasmacytoid dendritic cell infiltration, thereby leading to tumor growth.35, 36, 37. Here, HLA-DQB1 is linked to neoplasm.