For example, primary cells from transgenic mice lacking Cyld partially recapitulate the cellular hyperproliferation seen in CCS; and Cyld−/− mice treated with 12-O-tetradecanoylphorbol-13 acetate or ultraviolet light are more susceptible to mutagen-induced skin tumours (Jin et al., 2016; Massoumi et al., 2009). The gene discussed is CYLD; the disease is skin neoplasm.