As discussed at the beginning of this article, CYLD was discovered to be the gene responsible for CCS, an inclusive label for the inherited skin adnexal tumour syndromes Brooke-Spiegler syndrome (OMIM 605041), familial cylindromatosis (OMIM 132700) and multiple familial trichoepitheliomas (OMIM 601606) (Biggs et al., 1995; Bignell et al., 2000), by studying patient tumour and germline DNA of affected families. The gene discussed is CYLD; the disease is Brooke-Spiegler syndrome.