Other rarer causes of FTD and/or ALS include pathogenic variants in the genes encoding p62, TBK1 and optineurin, which are direct interactors with CYLD (Cirulli et al., 2015; Fecto et al., 2011; Freischmidt et al., 2015; Maruyama et al., 2010). Here, CYLD is linked to amyotrophic lateral sclerosis.