In addition to M719V, several rare CYLD missense variants have been identified in other European and Chinese ancestry patients with clinically diagnosed FTD (Dobson-Stone et al., 2020; Tábuas-Pereira et al., 2020; Xiao et al., 2022), ALS (Dobson-Stone et al., 2020; Gu et al., 2021) and Alzheimer's disease (Oyston et al., 2020; Xiao et al., 2022). Here, CYLD is linked to amyotrophic lateral sclerosis.