It has been shown that increased density of CD68+ tumor-associated macrophages (TAMs) is associated with increased vascular and lymphatic invasion in HNSCC (Pollard 2004; Kuang et al. 2007), and Vimentin is known to be associated with tumor growth and metastasis in cancer (Satelli and Li 2011). Here, VIM is linked to head and neck squamous cell carcinoma.