BIX‐01294 has been discovered as a potent anticancer drug via G9A inhibition, leading to cell death in G9A‐overexpressing bladder, lung, and breast cancer cells.[70, 71, 72] The underlying mechanism may be that BIX‐01294 induces ROS‐mediated autophagy and cell death in cancer cells.[73] Furthermore, BIX‐01294 was previously used as a replacement for OCT3/4 to generate induced pluripotent stem cells.[74] Culmes et al. This evidence concerns the gene POU5F1 and cancer.