Moreover, Lui et al. [49] demonstrated lower DNAm levels in the promotor region of PRDM16, measured in omental adipose tissue (OAT) in individuals with obesity compared with normal-weight subjects, suggesting a role for epigenetic regulation of PRDM16 in fat mass redistribution of peripheral iBAT to OAT in obesity. This evidence concerns the gene SLC10A2 and obesity due to melanocortin 4 receptor deficiency.